HIV-1 tat and rev upregulates osteoclast bone resorption

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

HIV-1 tat and rev upregulates osteoclast bone resorption

INTRODUCTION Disruption in bone homeostasis with increased osteoclastic resorption may lead to osteoporosis. HIV tat has been found to increase differentiation of precursor cells into osteoclast (OC) (1). Presence of soluble HIV proteins in virally suppressed HIV patients on ART may drive a bone resorption phenotype. We investigated the role of soluble HIV proteins (tat, gp120 Mn and Bal, rev a...

متن کامل

Chapter 3. Osteoclast Biology and Bone Resorption

66. Fuentealba LC, Eivers E, Ikeda A. Hurtado C, Kuroda H, Pera EM, De Robertis E M 2007 Integrating patterning signals: Wnti GSK3 regulates the duration of the BMP/Smadl signal. Cell 13 1 : 980-993. 67. Sapkota G, Alarcon C, Spagnoli FM, Brivanlou AH, Massague J 2007 Balancing BMP signaling through integrated inputs into the Smadl linker. Mol Cell 25:441454. 68. Nakayama K, Tamura Y, Suzawa M,...

متن کامل

Hypoxic regulation of osteoclast differentiation and bone resorption activity

Bone integrity is maintained throughout life via the homeostatic actions of bone cells, namely, osteoclasts, which resorb bone, and osteoblasts, which produce bone. Disruption of this balance in favor of osteoclast activation results in pathological bone loss, which occurs in conditions including osteoporosis, rheumatoid arthritis, primary bone cancer, and cancer metastasis to bone. Hypoxia als...

متن کامل

Osteoclast differentiation and bone resorption in multicentric reticulohistiocytosis.

Multicentric reticulohistiocytosis (MR) is a systemic disease of unknown cause characterized by the presence of a heavy macrophage infiltrate in skin and synovial tissues and the development of an erosive polyarthritis. The synovial fluid in MR is known to contain numerous mononuclear cells. In this study, we have determined whether these cells contribute to joint destruction in MR by different...

متن کامل

Inhibition of osteoclast differentiation and bone resorption by N-methylpyrrolidone.

Regulation of RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclast differentiation is of current interest in the development of antiresorptive agents. Osteoclasts are multinucleated cells that play a crucial role in bone resorption. In this study, we investigated the effects of N-methylpyrrolidone (NMP) on the regulation of RANKL-induced osteoclastogenesis. NMP inhibited RA...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of the International AIDS Society

سال: 2014

ISSN: 1758-2652

DOI: 10.7448/ias.17.4.19724